Wednesday, April 10, 2013

Maryland lawmakers pass medical marijuana bill

(AP) ? The Maryland General Assembly on Monday approved a measure allowing medical marijuana programs at research centers that choose to participate.

The state Senate approved the measure, 42-4. Ten of the Senate's 12 Republicans joined 32 Democrats, while two Democrats and two Republicans voted against it. The action sends the bill to Gov. Martin O'Malley, who indicated he is likely to sign the bill.

"I'd like to read it first, but I probably would," O'Malley told reporters.

The Democratic governor noted his decision would hinge on whether the bill includes provisions enabling the governor to suspend the program if the federal government decides to prosecute state employees who administer it. The provisions were included in the bill earlier this session, after Maryland Department of Health and Mental Hygiene Joshua Sharfstein said he would support the bill with the amendments. That was a change from last year, when Sharfstein expressed concern about potential federal prosecution.

Sen. David Brinkley, a Frederick County Republican, said concerns about medical marijuana violating federal law have been around for years, as more than a dozen other states and the District of Columbia have moved forward.

"At the same time, I think more and more as states start pushing the envelope on this thing, the federal government has to recognize that some of these cancer patients ? some of these people that are very sick ? you know, they're not doing this because they want to," Brinkley said. "They do feel that it's perhaps an element of last resort, and the last thing we want to do is criminalize who there are, why they're sick, that they're sick or their caregivers."

Delegate Dan Morhaim is a Baltimore County Democrat and emergency room physician who has been pushing to get the bill through for years. He emphasized that the program would be carefully supervised by academic medical centers.

While state analysts have projected programs would not be up and running until 2016, Morhaim said now that academic medical research centers have had a chance to look over the details, they are taking a closer look. Morhaim said Sinai Hospital in Baltimore has expressed interest in writing, even if it has not yet committed to participating. He also said Johns Hopkins has indicated it would take a closer look.

"They needed to wait to see what the road map looked like, and now that they have, I think you're going to see much quicker movement than people may have anticipated," Morhaim said.

Sen. E.J. Pipkin, R-Cecil, said he voted against the bill because he believes a comprehensive proposal on the legalization of marijuana for a variety of purposes should be put before voters, instead of piecemeal measures slowly moving through the Legislature.

"Let's let them vote on it," Pipkin said, referring to the state's voters.

While advocates said the measure was well-intentioned, they said it didn't go far enough.

"Maryland has taken a small step in the right direction, but more steps are necessary for patients to actually obtain the medicine they need to alleviate their suffering," said Amanda Reiman, a policy manager for the Drug Policy Alliance, in a statement.

The measure would create a commission within the state health department to oversee programs.

A participating medical center would be required to specify the medical conditions it would treat and the criteria by which patients would be allowed to participate. A medical center also would have to provide the state health department data on patients and caregivers on a daily basis. The department would also have to make the data available to law enforcement.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/bbd825583c8542898e6fa7d440b9febc/Article_2013-04-09-Medical%20Marijuana-Maryland/id-b78d297da4b646afaedb1c6e7fd86585

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Tuesday, April 9, 2013

Fisker Automotive lays off 75 percent of workforce | Digital Trends

Fisker Automotive surprised many of its employees last Friday morning by telling them to pack their things. The maker of the luxury plug-in hybrid laid off 75 percent of its workforce so quickly, in fact, that it is now facing a lawsuit.

In a statement, Fisker called the layoff ?a necessary strategic step in our efforts to maximize the value of Fisker?s core assets.? The financially troubled carmaker is currently seeking a buyer, and having more cash around would presumably make it more attractive.

A lawsuit filed in a California US District Court argues that Fisker?s actions are in violation of the US Worker Adjustment Retraining Notification (WARN) Act, which requires employers to give 60 days notice before a mass layoff.

The employees, represented by Sven Etzelsberger, the named plaintiff, are also demanding 60 days of ?wages, salary, bonuses, and other benefits.? Workers received no severance pay when they were laid off.

Fisker?s story has been nothing but bad news for the past few months. After a press battering over recalls, Karma production was shut down when battery supplier A123 Systems went bankrupt.

Needing cash to start production of the Atlantic, its proposed volume model, Fisker began looking for a suitor. Geely, the Chinese carmaker that already owns Volvo, appears interested, but no deal has gone down so far.

In the meantime, company founder and namesake Henrik Fisker resigned after a disagreement with other executives over business strategy.

With most of its workforce gone, it doesn?t look like Fisker intends to keep building cars. The small group of employees Fisker is retaining may just be around to manage a bankruptcy or court buyers.

Even if it does find a buyer, it?s unclear whether that buyer will be interested in the company as a whole, or just its cash, name and other assets.

Source: http://www.digitaltrends.com/cars/fisker-automotive-gets-slapped-with-lawsuit-after-laying-off-most-of-its-workforce/

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Retinoic acid gradient visualized for the first time in an embryo

Monday, April 8, 2013

In a ground-breaking study, researchers from the RIKEN Brain Science Institute in Japan report a new technique that allows them to visualize the distribution of retinoic acid in a live zebrafish embryo, in real-time. This technique enabled them to observe two concentration gradients going in opposing directions along the head-to-tail axis of the embryo, thus providing long-awaited evidence that retinoic acid is a morphogen.

The report, published today in the journal Nature, puts an end to a long-standing debate around the presence of retinoic acid gradients across the vertebrate embryo, during the early stages of development. It also sheds light on the role of retinoic acid in tissue development.

Retinoic acid has been thought to be a morphogen, a signalling molecule that diffuses throughout the embryo switching genes on and off and imparting different cell fates depending on its concentration. However, retinoic acid concentration gradients had never been visualized because retinoic acid cannot be tagged with the commonly used 'green fluorescent protein' GFP, or GFP-like proteins, as label.

"Until now no one had succeeded in monitoring the concentration of retinoic acid in real-time in a live embryo, and there was no direct data proving the existence of a retinoic acid gradient in the vertebrate embryo, explains Dr. Miyawaki, who led the research.

In order to monitor the concentration of retinoic acid in live zebrafish embryos at the early stages of their development, Dr. Miyawaki and his colleague Dr. Shimozono developed a technique to tag the molecule that acts as receptor for retinoic acid with genetically-encoded, coloured fluorophores. Based on the principle of fluorescence resonance energy transfer (FRET), the tags allow them to visualize the presence of retinoic acid and quantitatively determine its concentration over time.

By combining this technique with pharmacological and genetic manipulations, Miyawaki and his team demonstrate the presence of two linear retinoic acid concentration gradients across the antero-posterior axis of the embryo, from the trunk area to the head and the tail. Their findings suggest that retinoic acid diffuses quickly, thus establishing stable and robust gradients that are resistant to external perturbations.

"A better understanding of the gradients of retinoic acid is essential for research into the patterns of tissue development. It is necessary if we ever want to control the development of three-dimensional tissue structures from induced pluripotent stem cells, for regenerative medicine for example," concludes Dr. Miyawaki.

###

RIKEN: http://www.riken.jp/engn/

Thanks to RIKEN for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127627/Retinoic_acid_gradient_visualized_for_the_first_time_in_an_embryo

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Monday, April 8, 2013

Five Important SEO Strategies for Small Business Entrepreneurs ...

If you?re a small business owner or entrepreneur who promotes their business online, you should ensure that your website ranks high in web searches so customers can find you quickly when they?re looking for items you sell or services you provide. How to do that? Quite simply, incorporate SEO.

SEO or Search Engine Optimization is a strategy that improves the visibility of a website in organic search results (a.k.a. non-paid or natural search results) for a specified set of key phrases. SEO is extremely useful in that it offers you two invaluable assets:

  • The highest possible number of quality leads you can get, and
  • Targeted traffic

If you?ve been challenged with getting an increase in the numbers of potential customers who visit your website each day, try using the following strategies to pump up the volume:

1.?Know who your audience is and cater to them. This may seem easy, but a lot of companies don?t know who their target customer is and that is why their marketing plans fail. If you produce a breakfast cereal for children and your blog or website posts have no sense of fun or whimsy then you won?t be speaking the right language to the right people.

2.?Create valuable and useful content: As a business owner it?s your job to know everything there is to know about your goods and services. The challenge in sharing that information with the public is to know how to best encapsulate the facts for an online audience. Instead of posting staid and dry press releases on your site, try using video, images, polls and other interactive methods to educate and entertain your customers.

?3.?Be a social media smarty: If a company has a Facebook, Twitter or LinkedIn account, their posts are most likely to show up in search engine feeds. With this being the case, make sure the stories and information you?re pushing out is truly representative of your brand.

4.?Use dynamic keywords. When people search for information online they usually use Google and input keywords in order to find what they?re looking for fast. No one likes to spend hours looking for items to no avail. So when you?re creating blog posts or informative pieces for your website, it?s crucial to use buzz words within the content that are popular with search engines. If you operate a business that organizes helicopter tours in New York, what do you think the most important words are to use in your content? New York City, Helicopter and Tours. Sightseeing and tourists would be good words too.

5.?Feature impactful images with your posts. If keywords are crucial in SEO, images are just as important because they show up in internet engine searches as well and have a big role in getting people to click on an item. Also, due to the recent popularity of the social site Pinterest, more and more people are searching for and sharing images than ever before. Don?t let your news, posts and information get lost in the crowd.

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Source: http://www.techsling.com/2013/04/five-important-seo-strategies-for-small-business-entrepreneurs/

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How would you change the Droid Incredible 4G LTE?

http://www.blogcdn.com/www.engadget.com/media/2012/07/inc-review-lede-1341531069.jpg

Last summer, Verizon users who wanted an LTE-capable flagship had a stark choice: Samsung's Galaxy S III, or the Droid Incredible 4G LTE. When we reviewed the latter handset, we found it comfortable in the hand, with a pretty display, but lamented the fact that the carrier insisted upon its own variant, rather than sticking with the beloved One X. But did those Big Red-enforced tweaks ruin this handset for you? Here's the moment to share your experiences of this device, tell us what you loved, loathed and, if someone was listening, would you change?

Update: Perhaps we had Motorola on the brain, but of course the Droid Incredible 4G LTE is made by HTC. Thanks to everyone who pointed it out!

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Source: http://www.engadget.com/2013/04/07/hwyc-droid-incredible-4g-lte/

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Sunday, April 7, 2013

Oh, the places you won't go! World's 25 least-visited countries

Using UN statistics, travel writer?Gunnar Garfors found that top contenders for the least-visited award are often dangerous or remote. But some are just plain boring.

By Ryan Lenora Brown,?Correspondent / March 29, 2013

Somali men look out across Mogadishu's fishing harbor in the early morning as fishermen land their catch and transport their fish to the market in the Xamar Weyne district of the Somali capital, March 16. Somalia is the second-least visited country in the world, according to a recent list compiled by travel writer Gunnar Garfors from UN statistics.

Courtesy of Stuart Price/AU-UN IST PHOTO/Reuters

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For some travelers, getting off the beaten path is a point of pride, a way to see the parts of the world that don?t make it into glossy guidebooks.

Skip to next paragraph Ryan Lenora Brown

Correspondent

Ryan Brown edits the Africa Monitor blog and contributes to the national and international news desks of the Monitor. She is a former Fulbright fellow to South Africa and holds a degree in history from Duke University.?

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But how many of those same adventurous travelers would be willing to visit, say, Somalia?

About 500, it turns out.

At least, that?s how many tourists found their way to the wartorn east African nation last year. ?

That makes Somalia the second-least visited country in the world, after the tiny pacific island nation Nauru, according to a recent list compiled by travel writer Gunnar Garfors from UN statistics.?

Little Nauru ? 8.1 square miles in size, population 9,378 ? got just 200 visitors last year, and it?s pretty clear why.

?There is almost nothing to see there,? writes Mr. Garfors, ?as most of the island ? is a large open phosphate mine.??

Indeed, most of the world?s least visited countries seem to fall in one of two categories. There are the Naurus, where you?ll puzzle over what to do, and the Somalias, where it?s simply too dangerous to do much of anything at all. (As Somalia?s Wikitravel page aptly notes, ?the easiest method for staying safe in Somalia is not to go in the first place.?)?

Most of the ?nothing to do? countries are the crumbs that dust a map of the Pacific Ocean: the Federated States of Micronesia, the Solomon Islands, Kiribati, and Tuvalu. The latter shares with the Maldives the dubious distinction of having "highest elevation points" that are the lowest on earth ? 15 feet above sea level. Visit while you can, as rising sea levels could make the island uninhabitable within a century.

As for the ?too dangerous? countries, the list reads like a global primer in political conflict. For instance, despite its pristine national parks full of wild gorillas and elephants, the perpetually ungovernable Central African Republic (#23) is an unpopular destination for tourists. And its stock will likely continue to plummet ? last week a rebel alliance seized the capital, Bangui, and the president fled to neighboring Cameroon. (For more on the tempestuous politics of the CAR, read about the rebel alliance that took power there Sunday)

Afghanistan (#10) also suffers from tourism-deflating instability, which keeps visitors away from its rugged peaks, ancient Buddhist monuments, and Islamic holy sites, including the 12th-century Minaret of Jam, a UNESCO World Heritage Site.

?The Taliban have a message for foreign tourists who come to Afghanistan, especially if they are from any of the 50 countries that are part of the NATO-led coalition supporting the government: Big mistake,? writes The New York Times.

Other countries on the list, like Guinea Bissau (#14), Libya (#15), and East Timor (#18), have seen their reputations ? and infrastructure ? hobbled by recent wars or uprisings.

But not every country on the list is too dangerous or boring to visit. A few are simply effectively sealed off to the outside world.

All foreign visitors to North Korea (#16) are limited to a state-curated itinerary and must have an official government ?minder? by their side at all times. But for the few Western tourists who venture into the country, that?s part of the appeal. ?You will rarely get to see propaganda done more explicitly,? Garfors writes.

Except, perhaps, in Turkmenistan (#7), where visitors who brave the onerous Soviet-esque visa application process were, at least until 2010, rewarded with sites like a 50-ft. golden statue of former dictator Saparmurat Niyazov in the capital Ashgabat, which rotated throughout the course of the day to face the sun. But the country?s most indisputably impressive site is a massive flaming crater deep in the Karakum Desert. Measuring 230 feet across and almost 70 feet deep, the so-called ?Door to Hell? has been burning continuously since Soviet scientists lit it on fire in 1971. ?

Obscure? Yes. But that's part of the charm.

Source: http://rss.csmonitor.com/~r/csmonitor/globalnews/~3/NWsRTQMB3ZM/Oh-the-places-you-won-t-go!-World-s-25-least-visited-countries

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